Publications | Laura Grasa

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Publons

2024

Microbes and Parameters Influencing Dark Fermentation for Hydrogen Production

Gupta S, Fernandes A, Lopes A, Grasa L, Salafranca J.

Appl Sci. 2024 Nov 21; 14 (23). doi: 10.3390/app142310789.

Buttermilk and Whey as Functional Foods to Ameliorate Clindamycin-Induced Changes in Mouse Intestine: Modulation of Intestinal Motility and Toll-like Receptors Expression

Bellés A, Abad I, Buey B, Vergara C, Mesonero J.E, Sánchez L, Grasa L.

J of Medicinal Food. 2024 Nov 7; doi: 10.1089/jmf.2024.0155.

Antibacterial activity and antioxidant capacity of dairy kefir beverages

Aguirre-Ramírez D, Abad I, Pinilla E, Pérez M.D, Grasa L, Sánchez L.

International Journal of Dairy Technology. 2024 Oct 27; https://doi.org/10.1111/1471-0307.13153

Lactoferrin modulates oxidative stress and inflammatory cytokines in a murine model of dysbiosis induced by clindamycin

Abad I, Bellés A, Rodríguez-Largo A, Luján L, de Blas I, Graikini D, Grasa L, Sánchez L.

Biochem Cell Biol. 2024 Oct 8; doi: 10.1139/bcb-2024-0087

Photo-Fermentative Bacteria Used for Hydrogen Production

Gupta S, Fernandes A, Lopes A, Grasa L, Salafranca J.

Appl Sci. 2024 Jan 31; 14 (3). doi: 10.3390/app14031191.

2023

Whey and Buttermilk-Based Formulas Modulate Gut Microbiota in Mice with Antibiotic-Induced Dysbiosis

Bellés A, Abad I, Sánchez L, Grasa L.

Mol Nutr Food Res. 2023 Oct; 67 (20). doi: 10.1002/mnfr.202300248

Effect of in vitro gastrointestinal digestion on the antibacterial activity of bioactive dairy formulas supplemented with lactoferrin against Cronobacter sakazakii

Abad I, Serrano L, Graikini D, Pérez MD, Grasa L, Sánchez L.

Biometals. 2023 Nov 06; 36: 667-681. doi: 10.1007/s10534-022-00459-5

The Role of Lactoferrin in Intestinal Health

Conesa C, Bellés A, Grasa L, Sánchez L.

Pharmaceutics. 2023 Jul 13; 15 (6). doi: 10.3390/pharmaceutics15061569

Dairy By-Products and Lactoferrin Exert Antioxidant and Antigenotoxic Activity on Intestinal and Hepatic Cells

Abad I, Vignard J, Bouchenot C, Graikini D, Grasa L, Pérez MD, Mirey G, Sánchez L.

Foods. 2023 Jun 15; 12 (10). doi: 10.3390/foods12102073

Gut Microbiota-Derived Short-Chain Fatty Acids: Novel Regulators of Intestinal Serotonin Transporter

Buey B, Forcen A, Grasa L, Layunta E, Mesonero JE, Latorre E.

Life. 2023, April 26; 13 (5). doi: 10.3390/life13051085

Effect of a Ketogenic Medium Chain Triglyceride-Enriched Diet on the Fecal Microbiota in Canine Idiopathic Epilepsy: A Pilot Study

García-Belenguer S, Grasa L, Palacio J, Moral J, Rosado B.

Vet Sci. 2023, May 22; 10(4). doi: 10.3390/vetsci10040245

2022

Editorial: Molecular Mechanisms of Chronic Intestinal Diseases in Response to Microbiota
Grasa L.

Cells. 2022, Dec 29; 11 (23). doi:10.3390/cells11233722

Antitumor effects of lactate transport inhibition on esophageal adenocarcinoma cells.

Grasa L, Chueca E, Arechavaleta S, García-González MA, Sáenz MÁ, Valero A, Hördnler C, Lanas Á, Piazuelo E.

J Physiol Biochem. 2022 Nov 7; 79 (1): 147-161. doi: 10.1007/s13105-022-00931-3.

Editorial: Emerging talents in Frontiers in pharmacology: Gastrointestinal and hepatic pharmacology 2022.

Grasa L, Brzozowski T, Seelaender M.

Front Pharmacol. 2022 Oct 21; 13. doi: 10.3389/fphar.2022.1055030.

Protective effect of bovine lactoferrin against Cronobacter sakazakii in human intestinal Caco-2/TC7 cells.
Abad A, Sangüesa A, Ubieto M, Carramiñana JJ, Perez MD, Buey B, Mesonero JE, Grasa L, Sánchez L.

International Dairy J. 2022 Oct;133. doi: 10.1016/j.idairyj.2022.105428

Intestinal serotonergic system is modulated by Toll-like receptor 9.

Layunta E, Latorre E, Grasa L, Arruebo MP, Buey B, Alcalde AI, Mesonero JE.

J Physiol Biochem. 2022 Aug; 78(3):689-701. doi: 10.1007/s13105-022-00897-2.

TLR2 and TLR4 Modulate Mouse Ileal Motility by the Interaction with Muscarinic and Nicotinic Receptors.

Layunta E, Forcén R, Grasa L.

Cells. 2022 May 30; 11(11). doi: 10.3390/cells11111791.

Lactoferrin modulates gut microbiota and Toll-like receptors (TLRs) in mice with dysbiosis induced by antibiotics.

Bellés A, Aguirre-Ramírez D, Abad I, Parras-Moltó M, Sánchez L, Grasa L.

Food Funct. 2022 April 18; 13(10):5854-5869. doi: 10.1039/d2fo00287f.

Intrinsic and selective activity of functionalized carbon nanotube/nanocellulose platforms against colon cancer cells.

González-Domínguez JM, Grasa L, Frontiñán-Rubio J, Abás E, Domínguez-Alfaro A, Mesonero JE, Criado A, Ansón-Casaos A.

Colloids Surf B Biointerfaces. 2022 Apr; 212. doi:10.1016/j.colsurfb.2022.112363.

The Significant Influence of a Second Metal on the Antiproliferative Properties of the Complex [Ru(η6 -C10 H14 )(Cl2 )(dmoPTA)].

Kordestani N, Abas E, Grasa L, Alguacil A, Scalambra F, Romerosa A.

Chemistry. 2022, Jan 13; 28(3). doi: 10.1002/chem.202103048.

2021

Selective Anticancer and Antimicrobial Metallodrugs Based on Gold(III) Dithiocarbamate Complexes.

Abás E, Aguirre-Ramírez D, Laguna M, Grasa L.

Biomedicines. 2021 Nov 26; 9(12). doi: 10.3390/biomedicines9121775.

Gut Microbiota in Canine Idiopathic Epilepsy: Effects of Disease and Treatment.

García-Belenguer S, Grasa L, Valero O, Palacio J, Luño B, Rosado B.

Animals. 2021 Oct 31, 11(11). doi:10.3390/ani11113121

Effects of Dietary Supplementation with Protected Sodium Butyrate on Gut Microbiota in Growing-Finishing Pigs.

Bernad-Roche M, Bellés A, Grasa L, Casanova-Higes A, Mainar-Jaime RC.

Animals. 2021, Jul 19, 11(7) .doi:10.3390/ani11072137

Selective cytotoxicity of cyclometalated gold(III) complexes on Caco-2 cells is mediated by G2/M cell cycle arrest.

Abás E, Bellés A, Rodríguez-Diéguez A, Laguna M, Grasa L.

Metallomics. 2021 Jun 10; 13(7). doi: 10.1093/mtomcs/mfab034.

Comparative effect of bovine buttermilk, whey, and lactoferrin on the innate immunity receptors and oxidative status of intestinal epithelial cells.

Buey B, Bellés A, Latorre E, Abad I, Pérez MD, Grasa L, Mesonero JE, Sánchez L.

Biochem Cell Biol. 2021 Feb; 99(1):54-60. doi: 10.1139/bcb-2020-0121.

2020

Cyclometallated gold(III) complexes against colon cancer. X-ray structure of [Au(C,NPhenylpyridine)(OAc)2]

Abás E, Gómez-Bachiller M, Colom E, Pardina E, Rodríguez-Diéguez A, Grasa L, Laguna M.

J Organomet Chem 2020 August; 920. doi: 10.1016/j.jorganchem.2020.121340

New selective thiolate gold(i) complexes inhibit the proliferation of different human cancer cells and induce apoptosis in primary cultures of mouse colon tumors.

Abas E , Pena-Martinez R , Aguirre-Ramírez D , Rodriguez-Dieguez A , Laguna M , Grasa L .

Dalton Trans. 2020 Jan 3;49(6):1915-1927. doi: 10.1039/c9dt04423j.

Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics.

Vallan L, Hernández-Ferrer J, Grasa L, González-Domínguez JM, Martínez MT, Ballesteros B, Urriolabeitia EP, Ansón-Casaos A, Benito AM, Maser WK.

Colloids Surf B Biointerfaces. 2020 Jan 1; 185.

doi:10.1016/j.colsurfb.2019.110612.

2019

Anticancer Activity of Alkynylgold(I) with P(NMe2)3 Phosphane in Mouse Colon Tumors and Human Colon Carcinoma Caco-2 Cell Line.

Abas E, Espallargas N, Burbello G, Mesonero JE, Rodriguez-Dieguez A, Grasa L, Laguna M.

Inorg Chem. 2019 Nov 7; 58(22):15536-15551. doi: 10.1021/acs.inorgchem.9b02528.

Resveratrol reduces the spontaneuos contractions of rabbit duodenum

Santos-Fagundes D, Gonzalo S, Grasa L, Murillo MD.

Revista científica FVC-LUZ. 2019 Aug 18; 29(4): 260-264. Disponible en: https://produccioncientificaluz.org/index.php/cientifica/article/view/36548

Unique Properties and Behavior of Nonmercerized Type-II Cellulose Nanocrystals as Carbon Nanotube Biocompatible Dispersants.

González-Domínguez JM, Ansón-Casaos A, Grasa L, Abenia L, Salvador A, Colom E, Mesonero JE, García-Bordejé JE, Benito AM, Maser WK.

Biomacromolecules. 2019 June 28; 20(8):3147-3160. doi: 10.1021/acs.biomac.9b00722.

TLR2 and TLR4 interact with sulfide system in the modulation of mouse colonic motility.

Grasa L, Abecia L, Peña-Cearra A, Robles S, Layunta E, Latorre E, Mesonero JE, Forcén R.

Neurogastroenterol Motil. 2019 May 22; 31(9). doi: 10.1111/nmo.13648.

2018

NOD2 Modulates Serotonin Transporter and Interacts with TLR2 and TLR4 in Intestinal Epithelial Cells.

Layunta E, Latorre E, Forcén R, Grasa L, Castro M, Arias MA, Alcalde AI, Mesonero JE.

Cell Physiol Biochem. 2018 June 15;47(3):1217-1229. doi: 10.1159/000490218.

2017

Toll-like receptors 2 and 4 modulate intestinal IL-10 differently in ileum and colon.

Latorre E, Layunta E, Grasa L, Pardo J, García S, Alcalde AI, Mesonero JE.

United European Gastroenterol J. 2017 Aug 23; 6(3):446-453.

doi: 10.1177/2050640617727180.

NOD1 downregulates intestinal serotonin transporter and interacts with other pattern recognition receptors.

Layunta E, Latorre E, Forcén R, Grasa L, Plaza MA, Arias M, Alcalde AI, Mesonero JE.

J Cell Physiol. 2017 Oct 14 May; 233(5):4183-4193. doi: 10.1002/jcp.26229.

The lipopolysaccharide from Escherichia coli O127:B8 induces inflammation and motility disturbances in rabbit ileum

Grasa L, Gonzalo S, De Martino A, Murillo MD.

World Rabbit Sci. 2017 June 28; 25(2): 185-191. doi: 10.4995/wrs.2017.5160

2016

Intestinal Serotonin Transporter Inhibition by Toll-Like Receptor 2 Activation. A Feedback Modulation.

Latorre E, Layunta E, Grasa L, Castro M, Pardo J, Gomollón F, Alcalde AI, Mesonero JE.

PLoS One. 2016 Dec 29;11(12). doi: 10.1371/journal.pone.0169303

In-vitro toxicity of carbon nanotube/polylysine colloids to colon cancer cells.

Ansón-Casaos A, Grasa L, Pereboom D, Mesonero JE, Casanova A, Murillo MD, Martínez MT.

IET Nanobiotechnol. 2016 Dec 1; 10(6): 374-381. doi: 10.1049/iet-nbt.2015.0088

Antispasmodic Effects and Action Mechanism of Essential Oil of Chrysactinia mexicana A. Gray on Rabbit Ileum.

Zavala-Mendoza D, Grasa L, Zavala-Sánchez MÁ, Pérez-Gutiérrez S, Murillo MD.

Molecules. 2016 Jun 16; 21(6). doi: 10.3390/molecules21060783

Toll-like receptors 2 and 4 exert opposite effects on the contractile response induced by serotonin in mouse colon: role of serotonin receptors.

Forcén R, Latorre E, Pardo J, Alcalde AI, Murillo MD, Grasa L.

Exp Physiol. 2016 June 10; 101(8):1064-74. doi: 10.1113/EP085668

2015

Neomycin and bacitracin reduce the intestinal permeability in mice and increase the expression of some tight-junction proteins.

Nevado R, Forcén R, Layunta E, Murillo MD, Grasa L.

Rev Esp Enferm Dig. 2015 Nov;107(11):672-6. doi: 10.17235/reed.2015.3868/2015

Antibiotic-Induced Depletion of Murine Microbiota Induces Mild Inflammation and Changes in Toll-Like Receptor Patterns and Intestinal Motility.

Grasa L, Abecia L, Forcén R, Castro M, de Jalón JA, Latorre E, Alcalde AI, Murillo MD.

Microb Ecol. 2015 Oct;70(3):835-48. doi: 10.1007/s00248-015-0613-8

Toll-like receptors 2 and 4 modulate the contractile response induced by serotonin in mouse ileum: analysis of the serotonin receptors involved.

Forcén R, Latorre E, Pardo J, Alcalde AI, Murillo MD, Grasa L.

Neurogastroenterol Motil. 2015 Sep;27(9):1258-66.

Different mechanisms of actions of genistein, quercetin on spontaneous contractions of rabbit duodenum.

Santos-Fagundes D, Grasa L, Gonzalo S, Valero MS, Castro M, Arruebo MP, Plaza MÁ, Murillo MD.

Rev Esp Enferm Dig. 2015 Jul;107(7):413-6.

Roles of Toll-Like Receptor 4, IκB Kinase, and the Proteasome in the Intestinal Alterations Caused by Sepsis.

Gonzalo S, Valero MS, Martínez de Salinas F, Vergara C, Arruebo MP, Plaza MÁ, Murillo MD, Grasa L.

Dig Dis Sci. 2015 May;60(5):1223-31.

2014

Single-walled carbon nanotubes (SWCNTs) enhance KCl-, acetylcholine-, and serotonin-induced contractions and evoke oxidative stress on rabbit ileum.

Grasa L, Ansón-Casaos A, Martínez MT, Albendea R, De Martino A, Gonzalo S, Murillo MD.

J Biomed Nanotechnol. 2014 Mar;10(3):529-42. doi: 10.1166/jbn.2014.1732.

2013

Mechanism of action of Trolox on duodenal contractility.

Fagundes DS, Grasa L, Gonzalo S, Martinez de Salinas F, Arruebo MP, Plaza MA, Murillo MD.

J Physiol Pharmacol. 2013 Dec;64(6):705-10.

IL-10 modulates serotonin transporter activity and molecular expression in intestinal epithelial cells.

Latorre E, Mendoza C, Matheus N, Castro M, Grasa L, Mesonero JE, Alcalde AI.

Cytokine. 2013 Mar;61(3):778-84.

2012

Mitogen activated protein kinases blockade improves lipopolysaccharide-induced ileal motor disturbances.

Gonzalo S, Grasa L, Hernández LV, Arruebo MP, Plaza MÁ, Murillo MD.

Rev Esp Enferm Dig. 2012 Jun;104(6):305-9.

2011

Nuclear factor κB is a key transcription factor in the duodenal contractility alterations induced by lipopolysaccharide.

Hernández LV, Gonzalo S, Castro M, Arruebo MP, Plaza MA, Murillo MD, Grasa L.

Exp Physiol. 2011 Nov;96(11):1151-62.

Trolox reduces the effect of ethanol on acetylcholine-induced contractions and oxidative stress in the isolated rabbit duodenum.

Fagundes DS, Gonzalo S, Grasa L, Castro M, Arruebo MP, Plaza MA, Murillo MD.

Rev Esp Enferm Dig. 2011 Aug;103(8):396-401.

Role of TLR4 and MAPK in the local effect of LPS on intestinal contractility.

Barona I, Fagundes DS, Gonzalo S, Grasa L, Arruebo MP, Plaza MÁ, Murillo MD.

J Pharm Pharmacol. 2011 May;63(5):657-62.

Contractile effect of tachykinins on rabbit small intestine.

Valero MS, Fagundes DS, Grasa L, Arruebo MP, Plaza MÁ, Murillo MD.

Acta Pharmacol Sin. 2011 Apr;32(4):487-94.

Lipopolysaccharide-induced intestinal motility disturbances are mediated by c-Jun NH2-terminal kinases.

Gonzalo S, Grasa L, Árruebo MP, Plaza MÁ, Murillo MD.

Dig Liver Dis. 2011 Apr;43(4):277-85.

Extracellular signal-regulated kinase (ERK) is involved in LPS-induced disturbances in intestinal motility.

Gonzalo S, Grasa L, Arruebo MP, Plaza MÁ, Murillo MD.

Neurogastroenterol Motil. 2011 Feb;23(2):e80-90.

2010

Intestinal effects of lipopolysaccharide in rabbit are mediated by cyclooxygenase-2 through p38 mitogen activated protein kinase.

Gonzalo S, Grasa L, Fagundes DS, Arruebo MP, Plaza MÁ, Murillo MD.

Eur J Pharmacol. 2010 Dec 1;648(1-3):171-8.

Purinergic and nitrergic neuromuscular transmission mediates spontaneous neuronal activity in the rat colon.

Gil V, Gallego D, Grasa L, Martín MT, Jiménez M.

Am J Physiol Gastrointest Liver Physiol. 2010 Jul;299(1):G158-69.

Role of potassium channels in rabbit intestinal motility disorders induced by 2, 2'-azobis (2-amidinopropane) dihydrochloride (AAPH).

Hernandez L, Grasa L, Fagundes DS, Gonzalo S, Arruebo MP, Plaza MA, Murillo MD.

J Physiol Pharmacol. 2010 Jun;61(3):279-86.

Inhibition of p38 MAPK improves intestinal disturbances and oxidative stress induced in a rabbit endotoxemia model.

Gonzalo S, Grasa L, Arruebo MP, Plaza MA, Murillo MD.

Neurogastroenterol Motil. 2010 May;22(5):564-72, e123.

2009

P2Y(1) receptors mediate inhibitory neuromuscular transmission in the rat colon.

Grasa L, Gil V, Gallego D, Martín MT, Jiménez M.

Br J Pharmacol. 2009 Nov;158(6):1641-52.

2008

A downregulation of nNOS is associated to dysmotility evoked by lipopolysaccharide in rabbit duodenum.

Grasa L, Arruebo MP, Plaza MA, Murillo MD.

J Physiol Pharmacol. 2008 Sep;59(3):511-24.

Intestinal secretory and absorptive function in Trichinella spiralis mouse model of postinfective gut dysfunction: role of bile acids.

Kalia N, Hardcastle J, Keating C, Grasa L, Keating C, Pelegrin P, Bardhan KD, Grundy D.

Gut. 2008 Jan;57(1):41-9.

2007

Ca2+-activated K+ channels involved in duodenal dismotility induced by ethanol.

Fagundes DS, Grasa L, Arruebo MP, Plaza MA, Murillo MD.

Alcohol and Alcoholism. 2007 Jul-Aug;42(4):291-5.

2006

K+ channels involved in contractility of rabbit small intestine.

Lamarca V, Grasa L, Fagundes DS, Arruebo MP, Plaza MA, Murillo MD.

J Physiol Biochem. 2006 Dec;62(4):227-36.

The role of tyrosine kinase in prostaglandin E2 and vanadate-evoked contractions in rabbit duodenum in vitro.

Grasa L, Arruebo MP, Plaza MA, Murillo MD.

J Physiol Pharmacol. 2006 Jun;57(2):279-89.

PGE(2) receptors and their intracellular mechanisms in rabbit small intestine.

Grasa L, Arruebo MP, Plaza MA, Murillo MD.

Prostaglandins Other Lipid Mediat. 2006 May;79(3-4):206-17.

2005

The role of NO in the contractility of rabbit small intestine in vitro: effect of K+ channels.

Grasa L, Rebollar E, Arruebo MP, Plaza MA, Murillo MD.

J Physiol Pharmacol. 2005 Sep;56(3):407-19.

2004

The role of Ca2+ in the contractility of rabbit small intestine in vitro.

Grasa L, Rebollar E, Arruebo MP, Plaza MA, Murillo MD.

J Physiol Pharmacol. 2004 Sep;55(3):639-50.

International Dairy J. 2022 Oct;133. doi: 10.1016/j.idairyj.2022.105428

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2018